regex for search and replace -

I am searching one and changing it and all the characters need to change which no a comma "" .

How do I search for all the letters in any order?

For example:

  string, like this, will be  

...:

  to replace, replace, replace,  

any non-comma Matching the characters of: [^,] +

In such a perl: s / [^,] + / replace / g